The Rams and Kansas City were to have played there November 19 but the game was moved to Los Angeles because of poor field conditions.
The Chiefs were slated to play the Los Angeles Rams in Mexico City this past season.
The NFL announced the five games that will played as part of the International Series for the 2019 season.
In London, the NFC champion Los Angeles Rams will play Cincinnati.
The NFL will play two games at Tottenham Hotspur's new stadium, with two at Wembley Stadium.
The Jaguars - owned by Shad Khan, who also owns Fulham FC of the English Premier League - especially are used to global play.
The Jaguars, who are committed to play at least one game in London every season until the 2020 season, Chargers, Rams, Raiders and Buccaneers are designated the home teams. This will mark the seventh year in a row the Jags have played in London. Since the game was moved last minute, Chiefs fans who had already booked chose to meet up in Mexico City and cheer their team on from there.
Along with the Texans, the Carolina Panthers will be playing in London for the first time in their franchise history, bringing the "total number of National Football League teams to have played in the United Kingdom to 31 in 28 games", the Texans PR team said.