Danielle Collins advanced to the second round of a major for the first time following a 2-6, 7-6 (5), 6-4 win over No. 14-seeded Julia Goerges, who won the title in Auckland to start the season.
Ebden has three career wins over top-10 players, two of which came previous year.
Van Uytvanck, by contrast, falls to a 0-5 career record at the Australian Open and a second straight-sets loss to Wozniacki in as many meetings, having also previously fallen 6-1, 6-4 in the second round of Rome past year. NextGen Finals champion Stefanos Tsitsipas also went through in four sets.
She was the first of five Australian Open winners to play on Rod Laver Arena on Day 1, starting with a 6-0, 6-0 win over Harriet Dart.
"I mean, there is no time for that, I'm sorry to say", the 2008 victor said.
Playing in her 15th Australian Open, the three-time finalist said she was pleased to go through so easily as she battles back from injuries.
'I know, you were closing your eyes to be more focused on what I was saying, ' Nadal then continued, as he made light of the embarrassing situation.
The only break point Sharapova faced was when she double-faulted in the fifth game of the second set.
It seemed Boulter wasn't told, fist-pumping and walking to the net at 7/4 before being reminded of the new rule.
Boulter beat Ekaterina Makarova 6-0, 4-6, 7-6 (6), including 10-6 in the tiebreaker.
Rafael Nadal has poked fun at a journalist who appeared to fall asleep during his post-match press conference at the Australian Open on Monday. Nadal also hit 38 winners to just 11 unforced errors, a very clean match, but he was broken twice, so there is room for improvement for the Spaniard.
Scottish former world number one Murray tearfully revealed last week that severe pain from a hip injury was proving too much to bear and he planned to retire this year.
The humiliation had Dart weeping as she beat a hasty exit and Sharapova had little sympathy for the 22-year-old after her nightmare debut at Melbourne Park.
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