Arsenal's three goals after the break also maintained their seemingly schizophrenic record in the league this season, which has seen them score three times as many goals in the second halves of matches as they have in the first.
The Wales worldwide has spent over ten years at Arsenal, playing nearly 350 games for the club, and helping the Gunners win three FA Cup titles.
Aubameyang's early strike was cancelled out by two goals in four minutes from Spurs' England internationals Harry Kane and Eric Dier but three second-half goals from Aubameyang again, Alexandre Lacazette and Lucas Torreira earned Unai Emery's men three points and North London bragging rights, however temporary that may prove to be.
Aubameyang netted twice and Alexandre Lacazette was also among the scorers in Arsenal's 4-2 win (Nick Potts/PA).
And the former Cameroon defender who was a key member of the Invincibles has explained how the gaffer's decisions changed the game for the Gunners who are yet to lose a Premier League game since the back-to-back losses to Chelsea and Manchester City in August. "I would rather have Aaron Ramsey". Whether it is by accident or design is another matter.
Ozil was axed for the win over Bournemouth last weekend and Emery publicly suggested that the playmaker wasn't suited to playing in high intensity games amid reports he's concerned about the players work ethic.
While Emery changed 10 players from Thursday's Europa League trip to Kiev, for which he left his key players at home entirely, Mauricio Pochettino was working with a tired squad. "He was absolutely brilliant and set the tone for everything Arsenal have done". "We spoke and we knew that we could do it in the second half, to come back", Aubameyang himself noted.
"How many players on the halfway line miss the pass?"
The retired Germany worldwide missed the first north London derby of the season with a back spasm.
What this latest absence means for the 30-year-old's future at the club in unclear but with Emery proving successful so far, Ozil - unlike United's Paul Pogba, whose relationship with Jose Mourinho looks similarly complicated - may not be able to bide his time for a likely change of manager anytime soon.