This is Glenda's first Tony Award and she is now the 24th person to win the Triple Crown of Acting - a Tony, an Oscar, and an Emmy.
But musical Mean Girls, based on the 2004 film, went away empty-handed after receiving 12 nominations.
The Amazing Spiderman actor honoured the LGBTQ community saying, "It is a spirit that says no to oppression".
Taking the stage to introduce Bruce Springsteen's performance at the awards, the 74-year-old wasted no time with such a public opportunity.
The Band's Visit, a story of a group of Egyptian musicians who find themselves bonding with the residents of a small Israeli town, is a plea for tolerance and brotherhood, in a time when tensions are rising in the Middle East.
The beloved new Broadway production of Lynn Ahrens and Stephen Flaherty's Once On This Island has been named the 2018 Tony victor for Best Revival of a Musical!
The stage actress played the role of one of the gods, Goddess of Love, Erzulie, who helped Ti Moune get back with the man who has captured her heart. "To Paul Libin who said yes when we brought 1,000 pounds of sand, a hundred gallons of water, a goat and two chickens into his theater".
And - in something of a surprise - Steppenwolf Theatre ensemble member and "Roseanne" star Laurie Metcalf capped off an extraordinary career renaissance by winning a Tony for best featured actress in a play for her illuminative work at the core of Joe Mantello's widely acclaimed revival of Edward Albee's "Three Tall Women". Bareilles and Groban did a medley honoring Lifetime Achievement Award recipients Chita Rivera and Andrew Lloyd Webber, cast some Harry Potter spells and folded social media into the evening with the fun hashtag #TonyDreaming, which encouraged Twitter users to post pics of their early days in theater - whether it be in elementary, high school or otherwise. The not-quite Jewish co-hosts, Josh Groban and Sara Bareilles, were delightful, if aggressively wholesome.
As for the Audra connection, Mendez has tried to keep the six-time Tony victor out of mind while crafting her own take on the role. The revival of Angels in America had 11 and the two-part play Harry Potter and the Cursed Child had 10.
In her acceptance speech, telling Tony hopefuls to be true to themselves, Mendez said that when she had first moved to NY, she had been told she would need to change her name. Spacey's ceremony last year drew 6 million viewers, which represented a drop of approximately 31 percent in total viewers from the previous year.