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Pompeo's comments were welcomed by Israeli Prime Minister Benjamin Netanyahu, who said the demands amounted to "the only policy that could ultimately guarantee the security of the Middle East".

'The sting of sanctions will be painful if the regime does not change course from the unacceptable and unproductive path it has chosen to one that rejoins the league of nations, ' U.S. Secretary of State said. "These will indeed end up being the strongest sanctions in history when we are complete", Pompeo said in remarks at the Heritage Foundation.

French energy giant Total has also warned it will pull out of a multibillion-dollar project to develop Iran's vast South Pars gas field unless granted a waiver by USA authorities.

The Treasury Department already has reimposed sanctions on the head of Iran's central bank and other companies and groups, and Mr Pompeo warned: "The Iranian regime should know that this is just the beginning".

"Pompeo also threatened to "crush" Iran's terrorist proxies around the world".

The administration billed the speech, Pompeo's first policy address as secretary of state, as an articulation of Trump's new strategy toward Iran less than a month after he ignored the pleas of USA allies and withdrew from the nuclear accord.

"Our willingness to meet [North Korean leader] Kim Jong Un underscores the Trump administration's commitment to diplomacy to help solve the greatest challenges, even with our staunchest adversaries", said Pompeo.

In his speech, Pompeo gave short shrift to what the administration has been calling "fixes" to the nuclear deal, formally known as the Joint Comprehensive Plan of Action.

"We believe that is the right policy", Netanyahu said.

"We understand our re-imposition of sanctions and the coming pressure campaign on the Iranian regime will pose financial and economic difficulties for a number of our friends", Pompeo said. It let Iran keep its nuclear infrastructure and keep enriching uranium if not by as much. The requirement that nuclear inspectors get universal access would include military sites - long a red line for the regime.

Trump's decision to pull out of the Iran deal came despite pleas from USA allies that he not do so, while the move was celebrated by the Israeli government, which has long criticized the agreement.

"Iranians shouldn't play into the challenges and US radicalism", Heshmatollah Falahatpisheh told the Iranian Students News agency. Rouhani said in a statement carried by multiple Iranian news agencies.

Mike Pompeo addressed the Heritage Foundation with a speech regarding new USA policy towards Iran after Washington withdrew from JCPOA.

The US list also required Iran to cease backing Lebanon's Hezbollah, Gaza's Hamas, and the Palestinian Islamic Jihad. "But not its actions which jeopardize the world's citizens". In that crisis, the administration says it won't accept a strategy of synchronized, step-by-step concessions in exchange for North Korea gradually giving into demands to give up its nuclear program. The negotiators of the deal were the U.S., China, the European Union, Iran, France, Germany, Russia and the United Kingdom. He said the length of the list was simple testament to the "scope of the malign behavior of Iran".

As for the consequences, Pompeo was vague, saying only that Iran would be met with "steely resolve" if it continues on its current course. If the Iranians wanted a peaceful nuclear program, he added, "they would not hide their secret archives for making nuclear weapons". The secretary appealed to Iran's supreme leader, Ayatollah Ali Khamenei, a hard-liner, to "summon the courage to do something historically beneficial" for his people. The administration will then need to contemplate whether it is really willing to declare economic warfare on our own allies to force them out of a deal which, for now, Iran is in compliance with.