Last week, Trump's eldest son Don Jr. tweeted that West Virginia should oppose Blankenship.
President Donald Trump on Monday weighed in on the U.S. Senate race in West Virginia, urging Republican voters to reject combative newcomer Don Blankenship, a retired coal company executive, in favor of two more mainstream GOP candidates.
The Trumps were referring to December's special election where Republican Roy Moore won the Republican primary, and was defeated by Democrat Doug Jones.
Many on the right are concerned if Blankenship wins the primary, he'll nearly certainly lose the general election to Democratic Sen.
Blankenship spent a year in federal prison after being convicted of mine safety violations in the 2010 Upper Big Branch Mine explosion that killed 29 miners.
"West Virginia voters should remember that my enemies are Barack Obama and Hillary Clinton and my opponents would not even be running as Republicans had I not resurrected the Republican Party in West Virginia", Blankenship added.
"We don't think that even President Trump can stop it", Blankenship told Fox News.
"The President is a very busy man and he doesn't know me, and he doesn't know how flawed my two main opponents are in this primary", Blankenship said.
"I want to make sure (U.S. Senate Minority Leader) Chuck Schumer (D-N.Y.) is not the majority leader".
Public polling conducted in recent weeks showed Blankenship fading amid an avalanche of attacks from a super PAC aligned with Senate Majority Leader Mitch McConnell.
President Trump wrote,"To the great people of West Virginia we have, together, a really great chance to keep making a big difference".
A trio of incumbent Democratic senators representing states Donald Trump captured in the 2016 presidential election, Joe Donnelly of Indiana, Sherrod Brown of OH and Joe Manchin of West Virginia, will finally have a Republican opponent after Tuesday. He also is running television ads targeting the Taiwanese heritage of McConnell's wife, U.S. Transportation Secretary Elaine Chao. "I will win the primary and I will beat Joe Manchin".
Will Blankenship say the same thing about President Trump, whom he claims to support more closely than any of the other Republican candidates?
The ad also drew criticism for the use of the term "China family", to describe McConnell's in-laws.
West Virginia was considered a Democratic stronghold during the 20th century.
"I think he would follow in the exact same footsteps as our president", Newbrough said.
"Todd Rokita puts on a MAGA hat, he runs around the state, but on the tough votes...he's against President Trump", GOP Rep. Luke Messer said of his Republican House colleague Rokita in a debate last month.