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"Last year, (US) President Donald Trump said that the use of chemical weapons would violate a red line".

Leader of the Islamic Revolution Ayatollah Seyyed Ali Khamenei has condemned joint airstrikes by the USA, the United Kingdom and France on Syria as "crime", describing the leaders of the three Western states as "criminals", PressTV reports.

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The joint strike came after the White Helmets, a civil defense agency, blamed the Assad regime for the chemical attack, which it said killed 78 civilians and injured hundreds of others.

The Israeli military said Friday evening that following an "operational and intelligence-based investigation", its military has concluded that the "Iranian aircraft was armed with explosives and was tasked to attack Israeli territory".

Iran's involvement in Syria in support of Assad has alarmed Israel, which has said it will counter any threat.

"With their actions, the U.S.is deepening a humanitarian catastrophe in Syria", Russian President Vladimir Putin said, according to The Wall Street Journal. It was the basis for France's involvement in a joint military operation launched Saturday with the US and Britain to target Syrian chemical weapons facilities.

The Russian embassy in the USA released a statement saying "We warned that such actions will not be left without consequences", adding that Washington, Paris and London will be held accountable for them.

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Prime Minister Benjamin Netanyahu coupled praise for USA -led strikes on Syrian targets on Saturday with a warning that Iran's presence there further endangers Syria.

Stoltenberg said that the strike "will reduce the regime's ability to further attack the people of Syria with chemical weapons".

Immediately before Israel's claim that the Iranian drone was armed, the leader of the Lebanese terror group said that "The Israelis committed a historic mistake. and put themselves in direct combat with Iran", Nasrallah warned in a televised address.

"This massacre was a significant escalation in a pattern of chemical weapons use by that very awful regime", he said of the suspected deadly gas attack a week ago on the rebel-held Damascus suburb of Douma.

Pentagon officials said the attacks targeted the heart of Assad's programs to develop and produce chemical weapons.

Similar messages were passed from Washington to the Prime Minister's Office and the foreign ministry in Jerusalem, Ravid said. "Americans should expect the consequences of their actions", Javani said.

After the chemical gas attack by the Assad regime on civilians in Douma, an airstrike took place on the T4 air base in Syria.