Arsenal haven't won any of their last six Premier League meetings with Spurs (D4 L2) - their longest ever winless run against their rivals in league competition. They now sit third in the Premier League and are through to the last-16 of the Champions League.
Spurs, meanwhile, haven't been particularly successful against Arsenal away from home.
How should Arsenal line up against Tottenham on Saturday?
Tottenham Hotspur head into Saturday's 184th North London derby four points clear of Arsenal in the league.
And although Arsenal have won their last 10 Premier League games at the Emirates - their longest winning run at home since the stadium opened in 2006 - they have gone four home league games against Spurs without a victory, having last won on September 1, 2013.
And ahead of Saturday's derby, Piers Morgan, an avid Arsenal fan, has delivered a sensational message to Harry Kane.
He now feels confident that Tottenham will resist any more major players leaving, and believes they are staying on course for sustained success.
"I think Tottenham are a good side but we have the quality to win this game and that's what we want to show".
Wenger is hopeful the 32-year-old will return in January.
And Wenger says Arsenal will have to assess the situation on Monday.
"We still have some people coming in today".
"It is a massive challenge to.be competitive against a team that in last 20 years won more trophies than us".
Kane has scored in his last five games against Arsenal.
Pochettino had mixed news on the injury front, saying that Toby Alderweireld might be out until January because of a hamstring problem but that Harry Kane, Dele Alli, Harry Winks and Hugo Lloris had returned to training after injury.
Lacazette became Arsenal's club-record signing in the summer after arriving from Lyon, and has started all but two Premier League games.