Airbus's biggest previous sale came in August 2015 when it sold 250 A320neos to Indian budget airline IndiGo, a deal estimated to be worth 26 billion dollars (£20 billion) at list prices.
The purchase commitment, comprised of 273 A320neos and 157 A321neos worth 49.5 billion USA dollars at list prices, was announced at the Dubai Airshow by Bill Franke, Managing Partner of Indigo Partners, and John Leahy, Airbus Chief Operating Officer-Customers.
Boeing landed a $15.1 billion order for 40 787-10 Dreamliners from Emirates on Sunday.
Similarly, Airbus could see yet more orders before the year is out: this week it signed a provisional agreement with Kuwaiti company Wataniya Airways - which operates medium-haul flights across Europe and the Middle East - for a possible order of 25A320neo jets.
The American manufacturer won another deal from Fly Dubai, the city's low-priced carrier, for 225 737MAX jets worth $27 billion on Wednesday.
The transaction includes a new order for two freighters. The deal will spread the jets out across Frontier Airlines in the U.S., Mexico's Volaris, Wizz Air of Hungary and newcomer JetSmart of Chile.
"Regretfully, Indigo will not be paying $49.5bn", said Airbus sale chief John Leahy when asked about any possible discounts.
Despite the headline list price of the Indigo order, airlines typically get discounts on bulk-buys.
The Indigo Partners' airlines.
AerCap is the world's largest lessor of the Airbus A320neo; and the largest customer of the Boeing 787, with 116 on order and owned.
Kevin McAllister, Boeing Commercial Airplanes President and CEO said the deal marked a great day, and secured hundreds of jobs across the region and in the US.
The largest worldwide airline in the world, Emirates, made public today their over 15 billion dollars commitment for 40 Dreamliners of Boeing 787-10.
Emirati men visit the Dubai Airshow at its venue in Dubai.