Three people were killed in Ireland earlier this week as ex-hurricane Ophelia swept across the country at speeds of up to 96 miles per hour.
The storm system is forecast to smash into the United Kingdom with winds of around 70mph by Saturday morning, according to weather models.
South to south-easterly winds on Friday night are set to veer north-westerly on Saturday and are expected to reach yellow warning criteria at that stage.
Meanwhile the rest of the country are expected to receive less severe winds although they could still potentially reach 110kph.
"Those wind speeds can cause impacts to transport and power supplies, and the potential for risky waves also brings risks to coastal routes and communities, as well as the potential for flooding of homes".
Some transport disruption is likely across the warning area, with delays to road, rail, air and ferry transport.
The Met Office confirmed the storm system will turn into a "weather bomb" as it hurtles towards British shores.
Weather Company forecaster Dave Reynolds said "Brian" could also cause blackouts.
The Met Office added that an explosive cyclogenesis, or weather bomb, was forecast to take place which is caused when pressure drops by 24 millibars in 24 hours. We expect winds of 80mph perhaps stronger in coastal regions and although these might not be as strong as Ophelia it is important to note that many trees may have been weakened earlier in the week.
The status yellow warning predicts "heavy rain with accumulations between 30 and 50 mm possible".
The Met Éireann, the Irish Met Office, has issued an orange weather warning, with the nation once again expected to bear the brunt of the storm.
Despite Storm Aileen hitting the United Kingdom last month, and Ophelia earlier this week, Brian is the second, rather than third named storm of the year, as Ophelia was named as a hurricane.
"At the moment, Storm Brian is nothing to worry about here in Ireland".