Midfield duo Paul Pogba and Nemanja Matic return to the Champions league after over a year out of it, and look nailed on to start, with Marouane Fellaini potentially joining them in the middle of the park after missing the trip to Stoke on Saturday.
Mourinho confirmed that de Gea will continue in goal, and that Chris Smalling and Victor Lindelof would play in central defence amidst of Bailly and Jones.
"Benfica played Friday night", Mourinho added.
Jose Mourinho can not confirm if Marouane Fellaini will be fit enough to play against FC Basel, after the Manchester United midfielder missed the trip to Stoke City with a calf injury. "You're going to have to play them one way or another", said the England global ahead of Wednesday's visit of Dortmund.
"We are ready but we have to respect every opponent and realise where we have come from", Herrera said in comments published by the British press yesterday.
It's no surprise that Manchester United are runaway favourites to win the game given the clear gulf in quality between the sides.
But manager Mourinho is adamant it would be a huge blow if the former Everton player fails to play tonight - though his taking part in training yesterday seemed to at least give him a chance.
Victor Lindelof is set to make his Champions League debut for Manchester United when they host FC Basel at Old Trafford on Tuesday. "I trust them. I am not anxious at all that Bailly and Jones are out".
Manchester United have a pair of important players out suspended, with Phil Jones and Eric Bailly serving out bans earned in the Europa League last season. It is more comparable to the Portuguese style.
Manchester United kick off their first game of the group stages on the 12th of September against Basel at home and should they win the 3 points, it may ease the pressure for future games.
"I hope Old Trafford will welcome him as he deserves". Furthermore, this side was beaten at home in their last game in the Swiss Super League meaning that they are a full three points of the league leaders.
The Champions League group stage starts this week with Real Madrid looking to win Europe's top club competition for a third straight year, a feat not achieved since Bayern Munich in the 1970s.
"We have to try to qualify and we have to try to go to the last 16 and enjoy that special knock-out phase with the best teams in Europe".