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The fire has since grown to 5,000 acres and has been confirmed as the largest by acreage in Los Angeles City history, according to Mayor Eric Garcetti.

He added: "Our biggest concern is the wind and weather".

The blaze was 51 percent contained. No one has been injured.

The blaze has so far destroyed one house and forced the evacuation of almost 500 homes in various parts of the city and neighbouring Glendale. "If there's no wind, this is a relatively easy fire to put out". The fire ignited amid triple-digit heat in the San Fernando Valley.

Garcetti tweeted at 9:02 a.m. that the wind was calm and there was "no immediate threat to homes".

The center says more than 25,000 firefighters and fire support personnel are spread out across the Western U.S. fighting 56 large uncontained wildfires, 21 of them in Montana and 17 in Oregon.

An aerial shot of the La Tuna Canyon fire.

Los Angeles Fire Chief Ralph Terrazas said at 5 p.m. that the fire had spread to about 500 acres, and dozens of firefighters were working on the ground to halt the forward progress of the flames. "Last night we didn't see the fire lay down like we usually do in the evening". Due to erratic fire behavior, driven by strong, gusting winds, we are not able to give a firm prediction on all areas potentially at risk. Mandatory and voluntary evacuations have continued, with 730 homes evacuated across Burbank, Glendale, and the city of L.A., according to CBS. About 200 people have voluntarily evacuated.

The town of Topaz just south of the state line was evacuated as a precaution after the lightning-sparked blaze broke out Wednesday night. An evacuation center has been set up for displaced residents at both the Sunland Recreation Center in Sunland and at McCambridge Park in Burbank.

Nevada National Security Site spokeswoman Tracy Bower said Thursday that the fire covers nearly 4 square miles (10 square kilometers) in the western part of what used to be the Nevada Test Site. Officers from the Burbank Police Department went door to door informing residents of the order.

Los Angeles resident Tracy Goldman had her vehicle packed in case officials ordered her street to evacuate.

More than 500 firefighters from across the Southland have battled the blaze throughout most of Friday and well into Saturday morning. Firefighters sent additional resources to that neighborhood for structure protection and to assist with evacuations.

These mandatory evacuation areas in Brace Canyon Park include Haven Wy from Joaquin to the top, Olney Pl., Ramey Pl, Mystic View, and View Crest as of 10:40 p.m.

Silverman also stressed the importance of heeding evacuation orders.

"The air quality is bad", said Burbank police Sgt. Derek Green.

He says aircraft are attacking the flames that are chewing through sagebrush and cheatgrass in temperatures expected to reach triple digits. "Keep pets indoors and take care of each other".

"The La Tuna Fire is burning in 4 different directions to include down over the hills towards Burbank as well as north through the canyons above the 210 freeway".

The CHP had no estimate on when the closures would be lifted.

The fire began near the 10800 block of La Tuna Canyon Road shortly after 1 p.m., according to fire officials.

About a half-acre of medium brush was on fire when the first crews arrived Friday afternoon.

The brush fire north of Los Angeles also has shut down both sides of key freeway for holiday weekend travel. Roughly 260 of those were from the LAFD, she said.

"It's looking very, very good", Terrazas said.

"I think it's an wonderful feat to not have lost a life".

The blaze in thick brush that has not burned in decades was slowly creeping down a rugged hillside on Saturday toward houses, with temperatures in the area approaching 100 degrees Fahrenheit (38 degrees Celsius), the Los Angeles Fire Department said in an alert.