Someone had called about a "depression" under a boat parked next to the house in Lake Padgett Estates in Land O' Lakes.
Kevin Guthrie of the county's emergency management office told reporters the residents were out at work but firefighters rescued their dogs and removed some of their belongings.
Officials said a secondary structured has been impacted as the depression grows.
No injuries have been reported. It reached the roadway just after 8 a.m. and has swallowed two homes, according to ABC Action News.
Ten homes were evacuated because of the "active sinkhole" in Land O'Lakes, Florida, which officials said was "by no means stable".
By 9:30 am (local time) the home had fallen into the sinkhole.
Property records note a sinkhole confirmed in 2012 as "stabilised".
Deputies have cordoned off a portion of the neighborhood and are only allowing residents with identification into the area to get valuables from the evacuated homes - in some cases, accompanied by firefighters. "Mother Nature is going to take what Mother Nature takes".
The Red Cross is on the way to the scene to help families affected.