The Indian girls, brimming with confidence after upstaging England, would look to keep their winning momentum when they take on the West Indies in their second match of the ICC Women's World Cup, on Thursday.
Mandhana's unbeaten 106 off 108 balls, studded with 13 boundaries and two sixes, helped India chase down their target of 184 runs with 45 balls remaining.
India skipper Mithali Raj is in the most destructive form of her career and has scored consecutive seven half-centuries.
Stafanie Taylor, playing her 100th ODI, was run out for 16 by Mandhana's direct hit and Deandra Dottin - also earning her 100th cap - went for just seven when she picked out long off.
Raj was caught at mid-off as she failed to clear the circle off a delivery from West Indies off-spinner Hayley Matthews. The West Indies, on the other hand, lost by eight wickets to fancied Australia in their opening match. Along with the ever-dependable skipper Mithali Raj (46), Mandhana added 108 runs for the third wicket virtually shutting the World T20 champions out of contest. Eventually India have 2 wins in as many outings.
Former India cricketer Virender Sehwag led the plaudits for Mandhana, calling her "outstanding", while Snehal Pradhan, ex-India Women's player, too lauded the southpaw's century.
The West Indies have set a brilliant record in scoring runs and are consistently improving their rankings in ODIs, but are prone to sudden batting collapses.
Earlier, India's spin troika of left-arm spinners Poonam Yadav and Deepti Sharma, and off-spinner Harmanpreet Kaur restricted the West Indies to a lowly 183 for 8 in 50 overs.
The Indian innings was off to a poor start with West Indies pacer Shamilia Connell sending back opener Poonam Raut in the very first over.
Their first two ODIs were played on Friday, June 23 and on Sunday, June 25 at the Queen's Park Oval, Port of Spain.
The concern for India is running between wickets and wicket-keeping by an inconsistent Sushma Verma who missed two chances that oscillated the game towards England in the last match.
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