The race has been seen as a referendum on President Trump's tenure in office so far, and has already made history as the most expensive House contest ever.
Ossoff took to Twitter to urge constituents to "summon everything we've got" and troop to the polls despite rain falling on Georgia's sixth congressional district, as the president reiterated his support for Handel, 55.
The district's seat was vacated by Dr. Tom Price, who was appointed by Trump as Secretary of Health and Human Services earlier this year.
While Price routinely cruised to re-election in the 6th District, which encompasses many affluent, well-educated suburbs just north of Atlanta, this certainly wasn't Trump Country last November.
"KAREN HANDEL FOR CONGRESS", Trump said. The traditionally red suburban Atlanta district just barely tipped for Trump in November and Democrats are seeking to capitalize on backlash against the president.
epa06021377 Republican Karen Handel, a candidate for Georgia Congressional District 6 participates in a Get Out The Vote Rally at a restaurant in Marietta, Georgia on June 10 2017.
Norman is running in a closer-than-expected special election race against Democrat Archie Parnell, who has narrowed Norman's double-digit lead to within the margin of error of most polls. He raised $23 million for his campaign, but most of that came from outside of Georgia from liberal enclaves like NY and California.
HRC, alongside hundreds of volunteers, has been making calls at phone banks, sending action alerts and canvassing across the district to send a clear message that we strongly condemn Trump's discriminatory policies.
Ossoff is a former congressional staffer turned documentary filmmaker who has become a symbol of the anti-Trump movement.
There are 193 Democrats and three seats, including the one in Georgia, are vacant.
Both sides see national implications for the Ossoff-Handel matchup, which was believed to be close in the final hours. He described her as "a hard worker who will never give up!" before concluding with this ask: "VOTE TODAY".
For Roberts, Handel's agenda is tied too closely with Trump's.
Handel also attacked Ossoff for not agreeing to a nationally televised debate on a cable network.
Ossoff lives with his girlfriend who is attending medical school at Emory University in Atlanta.
National Republicans' House campaign arm added $4.5 million, and the U.S. Chamber of Commerce chipped in another seven figures.
Trump only won the district by 1.5 points. "They want someone with whom they can be connected, someone who knows the community, who has relationships in the community, who's been a part of this community for nearly 25 years", Handel said.
Outside GOP groups have spent $12 million to support Handel. Republicans are favored to hold a fourth seat on Tuesday in SC, while Democrats already held their lone open seat in a California special election.
There is another election on Tuesday, in SC, but the Republicans are expected to hold the seat, which was vacated when Mick Mulvaney became Mr Trump's budget director.