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Garry Shandling, best known for his series, It's Garry Shandling's Show and The Larry Sanders Show, is dead at the age of 66, ET confirms.

A cause of death has not been disclosed, but the Los Angeles Fire Department confirmed that it transported him to St. John's Medical Center after a report of a medical emergency at a home on Correa Way in Los Angeles at 10:40 a.m. Thursday. In 1981, he got his big break performing stand-up on The Tonight Show with Johnny Carson, and eventually became a frequent guest host on the show.

"The Larry Sanders Show", which ran from 1992 to 1998 on HBO, starred Shandling as the satirically exaggerated version of himself hosting a fictional late-night TV talk show.

Recently seen in Jerry Seinfeld's web-series Comedians In Cars Getting Coffee, Shandling is featured in The Jungle Book movie, which is set to be released in April.

Sunday, my longtime friend Garry Shandling was here, making every1 laugh.

Some may only know of him from his appearance in the Marvel Cinematic Universe as U.S. Senator and HYDRA member Stern, but if that is the extent of your knowledge on Shandling's life and career, then you've been missing out and should start catching up on his other work. Just heartbreaking." Comedian Albert Brooks wrote: "R.I.P. Garry Shandling.